the solubility enhancement of poorly soluble compounds is an important task in pharmaceutical technology as it leads to better bioavailability and a more efficient application. fused dispersions (fds) of simvastatin (sim) using peo-ppo block copolymer were prepared which paved the way for the formation of an amorphous product with enhanced dissolution and bioavailability. the accumulative solub...

It is shown that there exists an optimal spacing of thermo-sensors in the determination of the experimental heat transfer coefficient of a fluid flowing over a plate. The problem is considered as an inverse heat transfer problem with long thin fin model. The heat transfer coefficient of the fluid is estimated from simulated steady-state temperature measurements along the plate. It is shown theo...

In this paper, we report the numerical calculations for a thermo-optical model and the temperature sensitivity of a fiber Bragg grating (FBG) sensor. The thermally-induced behaviors of a FBG sensor in the gas nitriding process were analyzed for temperatures ranging from 100–650 ◦C. The FBG consisted of properly chosen photosensitive fiber materials with an optimized thermo-optic coefficient. Th...

We demonstrate a novel platform to control the thermo-optic sensitivity in nanophotonic devices by evanescent coupling of light with bimaterial cantilevers. The cantilever can be designed to provide a negative thermal feedback to passively compensate for the positive thermo-optic effect in the waveguide core. We demonstrate athermal operation over 14 deg in cantilever coupled Silicon ring reson...

This paper aims at describing a new method to simulate the locomotion of hemiplegic subjects. To this end, we propose to use inverse kinematics in order to make the feet follow a trajectory with respect to the root frame linked to the pelvis. The 11 degrees of freedom are then retrieved by inversing the kinematic function while taking other constraints into account. These constraints, termed se...

Standard numerical simulations for optimization or inverse identification of welding processes remain costly and difficult due to their multi-parametric aspect and inherent complexity. The aim of this paper is to propose a non-intrusive strategy for building computational vademecums dedicated to real-time simulations of nonlinear thermo-mechanical problems. There is in essence, a set of precomp...

Thermo-acoustic tomography is a hybrid medical imaging modality that aims to combine the good optical contrast observed in tissues with the good resolution properties of ultrasounds. Thermo-acoustic imaging may be decomposed into two steps. The first step aims at reconstructing an amount of electromagnetic radiation absorbed by tissues from boundary measurements of ultrasounds generated by the ...